The only problem I'm aware of is that it doesn't work with most Safe-Disc'd games. Safe-Disc is very widely used and this can be a major issue if this is your only drive. Since I also have a burner, I use that for games that don't work in the True-X drive.

Other than that, it's performed flawlessly. Two of my friends also have True-X drives (one has a 52X and one has as 72X). Both of them are also very happy with their drives (both also have another drive for loading Safe-Disc'd games).